Wide-linearity flexible OFET biosensors for wearable biomarkers detection

Flexible organic field-effect transistor (OFET) sensors, which leverage conjugated π-bonds in organic semiconductor layers to facilitate rapid charge transfer and enhance sensing sensitivity, offer significant advantages for detecting low concentrations of biomarkers in wearable biomedical electronics, such as glucose monitoring for diabetes. However, conventional OFET sensors suffer from a narrow linear range due to limitations in threshold voltage and saturation current. Therefore, a common problem in the field of the OFET-based biomarker sensing is that the narrow linear range of these sensors fails to meet detection requirements. This study addresses this challenge by expanding the linear detection range of OFET glucose sensors to 16.78 μM-1 M through the synergistic integration of four p-type and n-type OFET sensor array. Additionally, to ensure consistency in the fabrication of the sensor array, a fully printed processing technology using a bank structure was developed. Finally, a flexible epidermal continuous blood glucose monitoring system based on the wide-linearity OFET glucose sensor array was constructed to verify its practical feasibility.