Electrochemical Sensor Based on AuNPs/Cu/C for Simultaneous Detection of Acetaminophen and P-Aminophenol

In this work, Cu nanosphere-anchored Cu-based MOF derivants were synthesized by high-temperature calcination using Cu(BDC) as precursors and then combined with gold nanoparticles to give AuNPs/Cu/C composites. The proposed materials were characterized by SEM, XRD, XPS, FTIR, and EIS. Based on these composites, a sensor was constructed, which showed good electrocatalytic activities to the redox of acetaminophen (PA) and P-aminophenol (4-AP) and could be used to detect them simultaneously. Under optimal experimental conditions, the linear ranges for detection of PA and 4-AP were 0.50–150.00 and 0.50–120.00 μM with the detection limits of 0.056 and 0.084 μM, respectively. Thanks to the hierarchical and porous structural characteristics of the Cu/C material and its synergistic effect with AuNPs, it shows good sensing performance in the simultaneous detection of PA and 4-AP. The sensor has wider linear ranges, lower detection limits, good selectivities, and higher accuracies with potential environmental detection application prospects.