A molecularly imprinted electrochemical sensor based on dual functional monomers for trace determination of ramipril

A molecularly imprinted electrochemical sensor (MIECS) based on dual functional monomers was designed for the trace analysis of ramipril (RAM). The molecularly imprinted polymer (MIP) film was prepared by electropolymerization, p-aminobenzoic acid (p-ABA) and 2-amino-5-mercapto-1,3,4-thiadiazole (AMT) were used as dual functional monomers, and RAM was used as template molecule. Compared with sensors that only use a single functional monomer (p-ABA or AMT), the synergistic effect of dual functional monomers enhances the selectivity of MIECS. Under optimal conditions, the MIECS demonstrated a low detection limit of 23.9 fM within a wide linear range from 10 −13  M to 10 −6  M. Its application was validated by the successful detection of RAM in tablets with satisfactory recovery.