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Pd-Catalyzed Synthesis of Acyclic 1,2-Dioxygenated Dienes and Their Regioselective Decarboxylative Diels–Alder Cycloaddition/Aromatization Reactions to Access Multisubstituted Phenols

Journal 2025 · IF 3.6 · 发表于 2025 年 4 月 18 日
作者: Shuaikang Zhou,Siyi Qin,Xifang Zhang,Ying Song,Yuanfei Zhang
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摘要

A Pd-catalyzed protocol that provides efficient access to acyclic 1,2-dioxygenated dienes has been established. The installation of the bifunctional carbonate electrofuge to the diene cores enabled such dienes to undergo a regioselective decarboxylative Diels–Alder cycloaddition/aromatization reaction, affording diverse synthetic challenging multisubstituted phenols with ease.