Shape-adaptive multifunctional hydrogel based on in situ crosslinking of natural polyphenol-gelatin for wound treatment

Traditional wound dressings have problems such as a lack of bioactive substances, poor shape adaptability and secondary damage, which make it difficult to meet clinical needs. Therefore, this study developed a new type of photocurable hydrogel preparation (Ferulic acid-modified gelatin, GelFA) to promote wound healing. GelFA can be solidified in situ under ultraviolet light to form a hydrogel. Inspired by the compatibility of classical drug pairs, it is loaded with Bletilla striata polysaccharide (BSP) and notoginsenoside R1 (R1), which improves the moisturizing performance of GelFA but also synergistically promotes wound repair. GelFA/BSP-R1 hydrogel has excellent environmental adaptability, can prevent wound infection. At the same time, the hydrogel has anti-inflammatory, antioxidant, hemostatic and other functional properties. The results of cell experiments showed that GelFA/BSP-R1 hydrogel had good biocompatibility and significantly promoted angiogenesis, which laid a solid foundation for tissue repair. In wound models of rats and Bama pigs, it accelerates tissue repair by reducing inflammation, promoting collagen deposition, and accelerating angiogenesis. Inspired by the above research results, based on the new photocuring material GelFA, this study further developed various dosage forms to expand its clinical application. In summary, this study provides a promising new treatment strategy for clinical tissue regeneration.