Sprayable MXene composited carboxymethyl cellulose/pectin hydrogel with photothermal enhanced antibacterial for full-thickness skin wound healing

Natural polymer-based biodegradable hydrogels can be used to promote the wound healing due to their excellent biocompatibility, tissue adhesion and wound adaptability. In this research, a sprayable hydrogel with good antioxidant, skin adhesion and self-healing property was designed from hydrazide and dopamine functionalized carboxymethyl cellulose (CMC-HD) with oxidized pectin (OPec) cross-linking. The dopamine moiety enhanced antioxidant property of the hydrogel and the MXene nanosheets were composited to take the advantage of the photothermal stimulated antibacterial activit y . The coagulation drug Tranexamic acid (TXA) was loaded and enhance the hemostatic performance of the hydrogel in tail amputation and liver hemorrhage models. In vivo wound repairing experiment in full-thickness skin wound model proved the MXene@TXA/Gel promoted the wound repairing rate under NIR stimulus and this composite hydrogel shows great potential as wound dressing.