Octahedral Ce-MOF as electrochemical sensor for detection of chloramphenicol

An efficient Ce-MOF@Aptamer electrochemical aptamer sensing technology was established for the sensitive detection of chloramphenicol (CAP) in milk samples.Cerium-based metal-organic framework (Ce-MOF) was synthesized by using terephthalic acid as organic ligand and cerium nitrate as metal center. Subsequently, it was functionalized by EDC-NHS and covalently attached to the electrode, and then the functionalized aptamer was loaded to form a sensing platform. The octahedral Ce-MOF has a large surface area and can provide more binding sites for aptamers. The minimum detection limit of the sensor is 0.7 nM. In addition, the sensor can effectively detect CAP in milk samples with excellent selectivity, repeatability and stability.