Advanced Pt/PANI-Modified TiO2/PVAc Fiber Electrode for Enhanced Sensitivity in Glucose Detection

The global epidemic of diabetes urgently requires continuous and non-invasive glucose monitoring techniques. This article presents the development of a novel Pt/PANI-modified TiO 2 /PVAc nanofiber electrochemical sensor to address this challenge. In this research, the doping of Pt particles and PANI particles has effectively enhanced the electrochemical performance of the electrode. TiO 2 is first mixed with PVAc powder and then dissolved in an acetone/ethanol solution. Subsequently, fibers are fabricated through electrospinning technology and laid onto the electrode surface. The incorporation of TiO 2 offers more active sites for the deposition of Pt and PANI, thereby strengthening the stability of the overall structure. Furthermore, after the immobilization of Pt and PANI, the designed electrode demonstrates more outstanding performance in glucose detection. Experiments have shown that the peak current of the Pt/PANI/TiO₂/PVAc electrode in the electrochemical detection of glucose is 11 times that of the TiO₂/PVAc electrode. The results indicate that the ultimate electrode exhibits a detection limit of 0.001   mM, with a sensitivity of 7.818 μA·mM⁻¹·cm⁻², and a linear detection range spanning from 50   μM to 7   mM. These characteristics render it suitable for applications involving the detection of physiological glucose concentrations. This work demonstrated a promising step towards practical and effective wearable glucose monitoring, offering a safer and more convenient alternative for diabetes management.