Lewis base catalyzed N-selective allylation of sufenamides with Morita–Baylis–Hillman carbonates

A bstract A practical and N-selective allylation of sulfenamides using Morita-Baylis-Hillman carbonates under Lewis base catalysis is reported. It features broad substrate scope, high chemoselectivity, and tolerance to various functional groups, affording diverse N-allylated sulfenamides in good to excellent yields. Gram-scale experiments confirm its scalability, facilitating the synthesis of bioactive molecules and expanding the utility of sulfenamide chemistry.