Electrochemical sensor for urinary H2O2 detection to aid AKI diagnosis and treatment evaluation

Acute kidney injury (AKI), a critical clinical syndrome marked by high incidence and mortality, is currently diagnosed mainly by serum creatinine (SCr) and blood urea nitrogen (BUN), which have high miss rates. This study innovatively proposes using urinary hydrogen peroxide (H 2 O 2 ) concentration changes, caused by renal oxidative stress in AKI, as a new indicator for AKI risk assessment and treatment monitoring. Results from in vitro and AKI animal models show this indicator can quickly monitor AKI onset and drug effects in mice via electrochemical sensing technology based on Bi 2 S 3 @Cu 0.1 , offering a novel approach for AKI diagnosis and rehabilitation monitoring.