Preparation of Al-MOF with different ligands for efficient electrochemical determination of neohesperidin dihydrochalcone (NHDC) in mud films

In this paper, two Al-MOFs, named as MIL-53(Al) and NH 2 -MIL-53(Al), have been synthesized using aluminum ions as metal center and terephthalic acid, 2-aminoterepthalic acid as organic ligands in aqueous medium, respectively. Then, these two materials were utilized to construct the electrochemical sensor for the detection of neohesperidin dihydrochalcone (NHDC). The X-ray diffraction (XRD), scanning electron microscopy (SEM), fourier transformation infrared spectra (FT-IR), brunauer-emmett-teller (BET) and X-ray photoelectron spectra (XPS) were used to characterize the microstructure and morphology of two Al-MOFs materials. Compared with the MIL-53(Al) modified electrode, the NH 2 -MIL-53(Al) electrode proved a superior catalytic effect for the redox of NHDC. Thereafter, the electrochemical redox behavior and mechanism of NHDC at the NH 2 -MIL-53(Al) modified electrode were evaluated by cyclic voltammetry (CV), and the adsorption mechanism between the NH 2 -MIL-53(Al) materials and NHDC was revealed by density functional theory (DFT) calculations. Under the optimal detection conditions, a fast and sensitive strategy for detecting NHDC was constructed by differential pulse voltammetry (DPV). The linear range of NHDC based on this method was 0.08–30.0 μmol/L with R 2 = 0.9969. The low limit of detection (LOD) is 17.2 nmol/L for NHDC. Additionally, the NH 2 -MIL-53(Al) modified electrode demonstrated its applicability to the determination of NHDC in mud film samples with recoveries of 98.6–99.9 %. The consequences were in great accordance with high-performance liquid chromatography (HPLC), implying the feasibility of the proposed method for the detection of NHDC in actual samples.