Construction of silk fibroin-based composite nanofiber films with effective antibacterial and filtration properties

In recent years, respiratory infectious diseases have caused severe damage to human life and health as well as social development. New types of filtration and antibacterial materials have attracted widespread attention. In this work, chitosan quaternary ammonium salt (HACC) was used as antibacterial agents to prepare silk fibroin (SF)-based composite film materials with good antibacterial and filtration properties by electrospinning technology. The prepared composite film has good cytocompatibility and is free of irritation and allergenicity. In addition, the mask constructed with SF-based electrospun film as the filter layer material has an inhibition rate of more than 90 % against Escherichia coli and Staphylococcus epidermidis . Furthermore, the obtained electrospun film shows a good antibacterial effect on Staphylococcus epidermidis and Escherichia coli . This work provides new ideas for the preparation of new materials and their applications in mask filtration and antibacterial fields.