摘要
Hydrogels of exopolysaccharide gellan gum (GG) show great potential in biomedical areas. However, their weak mechanical properties and lack of functionality impede the practical applications. To address this, zeolitic imidazolate framework-8 (ZIF-8) nanoparticles were integrated into GG hydrogels via physical blending. X-ray diffraction confirms the successful incorporation and even distribution of ZIF-8 within the GG matrix. The novel composite hydrogels exhibit excellent mechanical properties without compromising the GG hydrogel's inherent thermoreversibility. Specifically, they achieve a maximum compressive strength and fracture energy of 0.85 MPa and 6.91 kJ·m −3 , and tensile strength and fracture energy of 95.09 kPa and 12.89 kJ·m −3 , respectively. They also display outstanding elasticity, resilience, and fatigue resistance, recovering approximately 86% after 10 compression cycles at 70% strain and over 70% after 10 stretching cycles at 200% strain. Notably, the composite hydrogels exhibit excellent swelling resistance in physiological saline, good biocompatibility, and enzymatic degradation by specific enzymes, with the equilibrium ratio lower than 56% and the minimum NIH3T3 cell viability higher than 86% after 24 h' incubation in the hydrogel extract. The excellent mechanics, eco-friendliness, and unique thermoreversibility and rheological properties suggest their suitability for applications in biomedical fields like 3D printable and repairable tissue engineering materials. Highlights ZIF-8/gellan gum composite hydrogels were fabricated via physical blending. ZIF-8 promotes the strength, toughness and resilience of gellan gum hydrogels. The composite hydrogels show good dimensional stability in physiological saline. They demonstrate good biocompatibility and can be degraded by specific enzyme. They are thermoreversible but with a lower transition temperature than GG hydrogel.
危险品化学品经营许可证（带存储）