Phenolic acids and their glycosides from the rhizomes of Cimicifuga dahurica

Phytochemical study on rhizomes of Cimicifuga dahurica resulted in the isolation of nine new neolignan and phenylpropanoid glycosides , cimicifugasides A-E ( 1, 2, 7–9 ), cimicifugamides B-D ( 3 – 5 ), shomaside G ( 6 ) along with four known compounds ( 10 − 13 ). Their structures were identified by extensive spectroscopic analyses (1D-, 2D-NMR, MS , CD, IR, UV) and chemical methods. Their anti-inflammatory potentials were evaluated by measuring their effects on PGE 2 production of LPS-stimulated RAW264.7 cells, and compounds 12 and 13 showed moderate anti-inflammatory activities.