A Pyridyl Zn (II) Chelate for the Sensitive Detection of Aβ Fibrils

Amyloid-β (Aβ) fibrils play a pivotal role in driving neuroinflammation and the progression of tau pathology in Alzheimer's disease (AD). In addition, Aβ oligomers are presumed to be closely associated with pathogenesis of AD. Currently, although a few Aβ antibodies are available, fluorescent probes still play an important role in detecting Aβ pathology. Herein, we designed and synthesized a pyridyl zinc chelate KZ and tested its potential specificity to Aβ species. The probe KZ showed a good binding to fibrillar Aβ aggregates and an excellent anti-interference feature in vitro. Importantly, KZ could display a subset of Aβ deposits recognized by OC antibody in brain sections of AD mouse models. Thus, this probe KZ could be used as a sensitive tracer for detecting Aβ fibrils or/and fibrillar oligomers.