One-Step Synthesis of Iodinated Polypyrrole Nanoparticles for CT Imaging Guided Photothermal Therapy of Tumors

Theranostic materials are of great significance to a personalized precise medicine. However, conventional theranostic agents are mainly fabricated by combining presynthesized independent imaging probes and therapeutic agents, suffering from multiple synthesis procedures, poor morphological control, and time/reagent-consuming process. Herein, iodinated polypyrrole (I-PPy) nanoparticles are fabricated via a one-step synthesis strategy combining chemical oxidation and iodination for computed tomography (CT) imaging-guided photothermal therapy. Iodic acid with a high standard electrode potential enables the chemical oxidation polymerization of pyrrole monomers. Meanwhile, the iodination of PPy induced by the corresponding reduction product I 2 takes place during the polymerization process to generate I-PPy nanoparticles. The prepared I-PPy nanoparticles possess a uniform size, excellent colloidal stability, intense near-infrared absorption, strong X-ray attenuation ability, and favorable biocompatibility. The as-synthesized I-PPy nanoparticles not only guarantee remarkable contrast-enhanced CT imaging of blood pool and tumors, but also realize effective tumor suppression in vitro and in vivo by I-PPy nanoparticles-mediated CT imaging-guided photothermal therapy. To the best of the authors' knowledge, it is the first time that multifunctional PPy nanoparticles are fabricated through a one-step synthesis process. The proposed strategy opens up a new way for the fabrication of high-performance theranostic agents via a one-step strategy under mild conditions.