Gold core-satellite nanostructure linked by oligonucleotides for detection of glutathione with LSPR scattering spectrum

We demonstrated a sensitive method for detection of glutathione (GSH) based on LSPR scattering spectrum using gold core-satellite nanostructure linked by T-Hg 2+ -T base pair . The core-satellite assembly caused coupling between plasmonic nanoparticles , which inducing distinct change of LSPR peak wavelength. As the interaction between Hg 2+ and GSH, the core-satellite nanostructure would be disassembled, which accompanied with spectral blue-shift of the scattering spectrum. By using this method, GSH could be quantitatively detected, and the detection limits can reach to 0.1 µM.