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Ultra-sensitive Nanoprobe Modified with Tumor Cell Membrane for UCL/MRI/PET Multimodality Precise Imaging of Triple-Negative Breast Cancer

Journal 2020 · IF 12.264 · 12(1): 1-14 · 发表于 2020 年 2 月 22 日
作者: Fang Hanyi,Li Mengting,Liu Qingyao,Gai Yongkang,Yuan Lujie,Wang Sheng,Zhang Xiao,Ye Min,Zhang Yongxue,Gao Mingyuan,Hou Yi,Lan Xiaoli
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摘要

A biomimetic nanoprobe was built with cancer cell membrane-coated and Gd 3+ -doped upconversion nanoparticles. The nanoprobe could be applied to in vivo UCL/MRI/PET multimodality precise imaging and successfully differentiated MDA-MB-231 tumor models through in vivo tri-modality imaging, which may be used for breast cancer molecular classification.