Mn-dox metal-organic nanoparticles for cancer therapy and magnetic resonance imaging

The high toxicity and side effects of drugs as well as the difficulty of tracking their trends and metabolism have always been the core difficulties of anticancer drugs. In this paper, doxorubicin (DOX) was used as therapeutic drug to coordinate with Mn 2+ to obtain the hydrophobic core of nanomedicine . The outer layer was self-assembled and coated with amphiphilic block copolymer-distearyl phosphatidylethanolamine-polyethylene glycol (DSPE-mPEG2000) to form [email protected] micellar nanoparticles (MDDM NPs) with good dispersion and stability. Cell experiments showed that MDDM micellar nanoparticles could be effectively uptaked by cells in a short time, and had good biocompatibility and tumor inhibition. In vivo experiments have shown that nanoparticles not only have excellent therapeutic effects, but also have magnetic resonance imaging contrast as contrast agents due to Mn 2+ coordination, which can assist in tracking drug trends and metabolism in vivo. The above work provides a certain reference significance for the study of combining organic drugs with metals to realize the reduction of drug toxicity and provide multimodal function of metals.