Synergistic Antibacterial Activity of Black Phosphorus Nanosheets Modified with Titanium Aminobenzenesulfanato Complexes

A two-dimensional (2D) antimicrobial nanoagent is synthesized by incorporating the titanium aminobenzenesulfanato complexes (Ti-SA4) onto black phosphorus nanosheets (BPs). The strong P–Ti coordination between Ti-SA4 and BPs results in the high loading capacity (∼43%) of Ti-SA4 onto BPs and enhances the stability of BPs against oxidation. Compared to bare BPs and Ti-SA4, the Ti-SA4@BPs exhibit improved antibacterial efficacy, and most of the bacteria are inactivated within 3 h with a dose of only 50 μg/mL. The underlying antibacterial mechanism is investigated. This proposed Ti-SA4@BPs have great potential in clinical applications, and the results provide insights into the design and synthesis of 2D antibacterial nanoagents.