Lignin-Containing Self-Nanoemulsifying Drug Delivery System for Enhance Stability and Oral Absorption of trans-Resveratrol

Self-nanoemulsifying drug delivery system (SNEDDS) is recently studied for enhancing the bioavailability of hydrophobic drugs, such as resveratrol (RSV). However, the functional design of SNEDDS for the drug structural protection is not studied yet. Here, this paper presents an efficient approach by adding lignin (a kind of abundant biomass resource) to enhance the stability of trans -RSV and meantime improve its oral bioavailability. Higher stability of trans -RSV (just decreased 2% to cis -RSV after 1 h under direct sunlight) is observed after loaded by lignin-containing SNEDDS (RSV/SLS SNEDDS). Low toxicity, high transfer efficiency (apparent permeability coefficient >1 × 10 −7 cm s −1 ), and bioavailability (1.371%) of RSV/SLS SNEDDS is successfully demonstrated in Caco-2 cells and rat model, respectively. This study serves to illustrate a simple, versatile, environmental, and economic sustainability approach to the development of nanodelivery systems for light instability drugs.