Near-infrared light-triggered drug delivery system based on black phosphorus for in vivo bone regeneration

A near-infrared (NIR) light-triggered drug delivery platform is produced by incorporating SrCl 2 and BP nanosheets (BPs) into poly(lactic- co -glycolic acid) (PLGA) for bone regeneration . The fabricated BP-SrCl 2 /PLGA microspheres show efficient NIR absorption and photothermal effects due to the BPs. The NIR-triggered release behavior of Sr 2+ by flawing the PLGA shells is investigated and the microspheres exhibit excellent cell viability and biodegradability . Implantation of the BP-SrCl 2 /PLGA microspheres into a rat femoral defect demonstrates good tissue compatibility and excellent bone regeneration capacity under NIR light irradiation. Our study indicates that local release of Sr 2+ at optimal time periods controlled by NIR irradiation improves bone regeneration significantly and this NIR-triggered drug delivery system composed of BPs is suitable for therapies requiring precise control at specific time.