摘要
Excessive UV irradiation induces photoaging and overproduction of melanin , which darkens the skin and affects appearance. To efficiently enhance transdermal delivery and anti-pigmentation, a novel ROS-responsive transdermal nanocarrier for the whitening agent Glabridin by integrating the cell-penetrating peptide polyarginine R8 and borate ester bond into hollow mesoporous silica nanoparticles (HMSNs) has been designed, in which beta-cyclodextrin (β-CD) was grafted onto the surfaces of HMSNs via boronic ester bond to avoid premature release of Glabridin, and R8 conjugated adamantane (Ada) was anchored on HMSN-β-CD via host-gust interaction to enhance the drug delivery efficiency. The ROS-responsive HMSN-β-CD/Ada-R8 nanocarrier was characterized by TEM, FTIR , TGA , Zeta potential , N 2 adsorption, stability, and other parameters. The nanocarrier rapidly penetrated through the epidermis into the keratinocytes and melanocytes and released Glabridin in a controlled ROS-responsive manner. Glabridin released from nanocarriers reversed UV-induced oxidative damage and phototoxicity and reduced hyperpigmentation. Taken together, our study provides a guidance for the design and fabrication of functional transdermal drug nanocarriers for cosmetic applications.
危险品化学品经营许可证（带存储）