Preparation and drug release behavior of TiO2 nanorod films with incorporating mesoporous bioactive glass

For orthopedic implant coatings, excellent biological performance and anti-infective property have been both increasingly required for implantation surgery. In this work, TiO 2 nanorod films with good cellular responses and mesoporous bioactive glass (MBG) with good drug loading and release ability were adopted, and MBG-incorporated TiO 2 nanorod films were prepared by the sol–gel technique. The effects of TiO 2 nanorod density and MBG composition on the formation of the incorporated films were investigated. The results show that T-MBG (SiO 2 /CaO/P 2 O 5 /TiO 2   =   80/5/5/10) tightly cohered to TiO 2 nanorods in the films, and the degree of T-MBG incorporation ranged from about 100   nm to 300   nm of exposed TiO 2 nanorods in height. T-MBG incorporation had a positive role in the cytocompatibility of the films. Importantly, T-MBG incorporation improved greatly the drug release behavior of the TiO 2 nanorod films. The present work provides an approach to build organized nanostructure films on implant surfaces with satisfactory biological performance and essential anti-infective ability.