CuI-catalyzed synthesis of 2-(tert-butyldisulfanyl) heterocycles from 2-mercaptoheterocycles and tert-butanesulfinamide

Abstract The valuable 2-( tert -butyldisulfanyl)heterocycles were effectively synthesized from 2-mercaptoheterocycles and tert -butanesulfinamide via unusual condensation. The reaction between 2-mercapto sulfur-containing heterocycles and tert -butanesulfinamide was performed under ligand-free CuI-catalyzed conditions. The synthetic processes described herein are simple, cost-efficient, and practical. Furthermore, a plausible mechanism is proposed for this transformation. Graphical abstract