Odorless, Transition-Metal-Free N-Sulfenylation of Sulfoximines with Thiosulfonates under Mild Conditions

Graphical An odorless and efficient synthesis of N -sulfenyl sulfoximines has been developed through the electrophilic sulfurization of thiosulfonates with sulfoximines. The reaction was carried out under mild conditions without transition metal catalysis, heating, and the use of toxic reagents. N -Sulfenylation of sulfoximines with thiosulfonates under mild conditions was disclosed. By our method, a series of aliphatic and aromatic N -sulfenyl sulfoximines were synthesized with good to excellent yields in the absence of transition metals. The applicability of this method was demonstrated by gram scale experiments.