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Synthesis of novel spiro[cyclopropane-pyrrolizin] derivatives via Mg-mediated conjugate addition of bromoform

Journal 2013 · IF 0.88 · 41(4): 2345-2352 · 发表于 2013 年 8 月 9 日
作者: Liu Bin,Li Xiao Fang,Zhang Jie,Wang Meng Ting,Zeng Rong Jin
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摘要

The conjugate addition of bromoform with 2-aryliene-2,3-dihydro-1 H -pyrrolizin-1-ones in the presence of magnesium afforded novel 2,2-dibromo-3-arylspiro[cyclopropane-1,2′-pyrrolizin]-1′(3′ H )-ones in moderate yield. The structures of all the products were characterized thoroughly by 1 H NMR, 13 C NMR, infrared spectroscopy, and mass spectrum.