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Cu(OAc)2/Malononitrile/Water: A Simple Reaction System for Synthesis of Aromatic Nitriles from Aldoximes

Journal 2018 · IF 0.668 · 发表于 2018 年 12 月 1 日
作者: Xiaoyun Ma,Daqin He,Zhengjian Chen
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摘要

A simple method for the preparation of nitriles in moderate to good yield has been achieved by treatment of aromatic and heterocyclic aldoximes with malononitrile in water at reflux in the presence of copper acetate as catalyst. Arylaldoximes with an electron-donating group showed the highest reactivity, their conversion being achievable at room temperature.