Synthesis of arylacylated oxindoles via visible light-promoted Smiles rearrangement

Graphical Various arylacylated oxindoles are synthesized from the visible-light- promoted tandem reaction of N-arylsulfonyl-acrylamides with α-oxocarboxylic acids. The products are obtained under mild conditions. A visible-light-promoted radical tandem reaction of N-arylsulfonyl-acrylamides with α-oxocarboxylic acids is described. It undergoes decarboxylation, Smiles rearrangement, and intramolecular cyclization under mild reaction conditions, providing a series of arylacylated oxindoles with potential pharmacological activities.