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Formation of Methylene Linkage for N-Heterocycles: Sequential C–H and C–O Bond Functionalization of Methanol with Cosolvent Water

Journal 2019 · IF 4.745 · 发表于 2019 年 5 月 15 日
作者: Na Li,Jinku Bai,Xiaolin Zheng,Honghua Rao
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摘要

An iron-catalyzed methylene forming strategy is disclosed through sequential C–H and C–O bond functionalization of methanol with cosolvent water. This protocol provides an easy and novel access to methylene-tethered imidazo[1,2-a]pyridine and 2-aminopyridine analogues in a sustainable manner and represents a complementary approach to traditional methylene forming strategies.