A New Photoluminescent 3D Supramolecular Zn(II) Complex and Its Therapeutic Effect on Diabetic Ocular Complications

The hydrothermal reaction among Zn(NO3)2 · 6H2O, 1,3,5-benzenetricarboxylic acid (H3BTC), and 7-hydroxy-5-methyl-1,3,4-triazaindolizine (Hmtpo) synthesized a fresh complex of [Zn(HBTC)(HATAZ)(H2O)2] n · 2n(H2O) · n(Hmtpo) (1, HATAZ is 3-amino-1,2,4-triazole). This supramolecular framework showed intense luminescence emission at RT. For treating diabetic ocular complications, the preventive and therapeutic effects of the compound on diabetic ocular complications were analyzed, and the detailed mechanism was investigated. ELISA was conducted to examine the inflammatory cytokines generated through the fundus arterial endothelial cells. Furthermore, RT-PCR was carried out to determine the oxidative stress level in the fundus arterial endothelial cells.