Synthesis, characterization, and biological evaluation of a novel Zn(II)-Naproxen complex

A novel Zn(II)-Naproxen complex [Zn(nap) 2 (dap)] containing 1,3-diaminopropane ligand was synthesized and characterized by FT-IR, UV–Vis, elemental analysis and 1 H NMR spectroscopy, its single crystal structure was confirmed by X-ray crystallography. The new Zn(II)-Naproxen complex was evaluated in vivo for its anti-inflammatory, ulcerogenic and analgesic activities, in vitro for antibacterial and antioxidant activities, which showed superior biological properties compared with Naproxen. The edema inhibition rate for the complex reached 57.8% after 3 h, pain inhibition value was 71%, and ulcer index was 8 ± 1. Furthermore, the antibacterial and antioxidant activities of Zn(II)-Naproxen complex were tested showing better effects than Naproxen.