A Novel Fast Responsive Thermo-Sensitive Poly(N-isopropylacrylamide)-Clay Nanocomposites Hydrogels Modified by Nanosized Octavinyl Polyhedral Oligomeric Silsesquioxane

The preparation of a novel fast response thremosensitive hydrogel was investigated by incorporating nanosized octavinyl polyhedral oligomeric silsesquioxane (OvPOSS) particles into inorganic clay-crosslinked poly(N-isopropylacrylamide) (PNIPA) nanocomposites hydrogels (NC gels). The resulting hydrogels named as P-NC gels involving both the strategies of NC gels and double network gels (DN gels) were successfully synthesized via a two-step technique. The second PNIPA network crosslinked by OvPOSS were polymerized in the presence of the first clay-PNIPA network. The P-NC gels were characterized by FTIR, X-ray, DSC, UV/vis spectra, SEM, mechanical properties and swelling behaviors measurements. The key factor for preparing homogenous P-NC gels with good transparency was the low concentration of OvPOSS (c OvPOSS) dispersed uniformly in polymer as a cross-linker. On the contrary, the high c OvPOSS led to the significant aggregation of the OvPOSS particles and thus resulted in the heterogeneity of gels. The SEM images of freezedried P-NC gels exhibited a highly interconnected microporous network structure, which could be adjusted by varying the amount of OvPOSS. The special porous morphology brought about an attractive faster swelling/deswelling rate than that of normal NC gels. All properties of P-NC gels displayed an obvious dependence on the concentration of incorporated OvPOSS. The excellent mechanical properties, tunable LCST, especially the fast deswelling rate make these hydrogels potential candidates for applications in drug release and other biological fields.