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Rhodium(III)-Catalyzed Oxidative Olefination of Picolinamides: Convenient Synthesis of 3-Alkenylpicolinamides

Journal 2014 · IF 5.542 · 356(5): 1038-1046 · 发表于 2014 年 3 月 11 日
作者: Jun Zhou,Bo Li,Zhen-Chao Qian,Bing-Feng Shi
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摘要

A rhodium(III)-catalyzed selective olefination of picolinamide derivatives has been developed. The reaction shows high regioselectivity, low catalyst loading (0.5 mol%), high yield and good functional group tolerance, providing a convenient strategy for the synthesis of 3-alkenylpicolinamides.