Tandem, Effective Continuous Flow Process for the Epoxidation of Cyclohexene

In this study, a novel protocol consisting of peroxidatic reaction and epoxidation process was developed. Besides, a specific continuous extraction apparatus was also employed in the continuous flow synthesis process. Without additional purification, m-chloroperbenzoic acid (m-CPBA) generated in situ could react with cyclohexene, leading to high quality cyclohexene oxide. In the first stage, m-CPBA was obtained within a few seconds at room temperature by reacting m-chlorobenzoyl chloride with hydrogen peroxide, while cyclohexene oxide was prepared at 30 °C for 10 min in the following stage.