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A Convenient Synthesis towards 2-Bromo-2-(methoxy(phenyl)methyl)malononitrile and 2-Iodo-2-(methoxy(phenyl)methyl)malononitrile

Journal 2022 · IF 0 · 2022(2): M1373 · 发表于 2022 年 5 月 30 日
作者: Jialuo Chen,Lili Duan,Kunming Liu,Jin-Biao Liu
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摘要

This short note elaborates a concise protocol for the synthesis of two novel vicinal haloethers bearing a malonontrile group, 2-bromo-2-(methoxy(phenyl)methyl)malononitrile (1) and 2-iodo-2-(methoxy(phenyl)methyl)malononitrile (2). The structures of the synthesized compounds were confirmed by 1H, 13C-NMR spectroscopy. The final products indicate that methanol not only acts as solvent but also participates in and dominates the reaction result.Keywords:β;β-dicyanostyrene;difunctionalization;vicinal haloether