CdTe quantum dots and gold nanoparticle based spectral methods for determination of lincomycin

Two novel and convenient methods for the determination of lincomycin (LCM) in aqueous solutions have been developed. The first method was based on the enhanced fluorescence of thioglycolic acidcapped CdTe quantum dots (TGA-CdTe QDs) by LCM. For the second method, the introduction of LCM could induce the aggregation of gold nanoparticles (AuNPs), displaying distinct changes in color and in UVvis spectra. Under optimal conditions, the enhanced fluorescence intensity was linearly proportional to LCM concentration in the range of 1–240 μg mL −1 with a detection limit of 2.63 × 10 −1 μg mL −1 . The second platform is capable of determining LCM in ranges from 1.00 × 10 −3 to 2.00 × 10 −2 μg mL −1 and from 3.00 × 10 −2 to 1.20 × 10 −1 μg mL −1 with a detection limit of 1.27 × 10 −4 μg mL −1 . Both methods were used for rapid detection of LCM in real samples with satisfactory results. Comparisons between the two methods were made.