Visible-light-promoted Cascade Reaction of Acryloylbenzamides with Carboxylic Acids: Metal-free Synthesis of Isoquinolinediones

Graphical A visible light-promoted cascade reaction of acryloylbenzamides with carboxylic acids and α-imino oxy acid is established. A series of 4-substituted isoquinolindiones are obtained in satisfied yields. A metal-free and mild cascade reaction of acryloylbenzamides with carboxylic acids and α-imino oxy acid is developed. It undergoes decarboxylation, radical addition, and intramolecular cyclization in the presence of visible light, providing 4-substituted-isoquinoline-1,3(2H,4H)-diones in moderate to good yields.