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Enzyme-catalyzed direct three-component aza-Diels–Alder reaction using lipase from Candida sp. 99–125

Journal 2016 · IF 1.947 · 发表于 2016 年 10 月 20 日
作者: Dong-Hang Yin,Wei Liu,Zhi-Xiang Wang,Xin Huang,Jing Zhang,De-Chun Huang
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摘要

The direct three-component aza-Diels–Alder reaction was conducted with lipase as a catalyst for the first time. Under the optimized conditions, the aza-Diels–Alder reaction catalyzed by lipase from Candida sp. 99–125 provided the products in moderate to excellent yields. Meanwhile, the endo / exo ratio reached up to 88:12.