Triterpene Saponins from the Stems of Entada phaseoloides

Ten new triterpene saponins (1–10) have been isolated from the stems of Entada phaseoloides. Their structures were elucidated by spectroscopic analysis and chemical methods. Among these compounds, the aglycons of 6–10 are being reported for the first time, in this study, including 3β,15α,16α-trihydroxy-11α,12α-epoxy olean-28,13β-olide (6), 3β,15α,16α-trihydroxy-11-oxo-olean-12-en-28-oic acids (7 and 8), and 3β,15α,16α-trihydroxy-oleana-11,13(18)-dien-28-oic acids (9 and 10). The cytotoxic activities of all of these compounds were evaluated against HepG-2, A549, and Ec-1 cell lines.