MODELS FOR LIPOXYGENASE WITH TWO ALKOXIDE–Fe(III) CENTERS: SYNTHESIS, STRUCTURES, AND PROPERTIES

Abstract [Fe III (OMe)(Hedtb)](ClO 4 ) 3 ·6.5CH 3 OH ( 1 ) and [Fe III (O n- Bu)(Hedtb)](ClO 4 ) 3 ·3 n -BuOH ( 2 ) (edtb =  N,N,N′,N′-tetrakis[(2-benzimidazolyl)methyl]-1,2-ethanediamine) were prepared and display lipoxygenase activity. X-ray crystallography reveals that the Fe III centers in complexes 1 and 2 are ligated to three nitrogens of benzimidazole and two alkylamine nitrogen atoms from the edtb ligand, with a terminal alkyoxyl group occupying the sixth position. Complexes 1 and 2 both possess a Fe III –O R center ( R  = Me, 1 ; n -Bu, 2 ) with Fe–O bond distances of 1.799(3) Å and 1.789(5) Å, respectively. The UV-Vis spectra and electrochemical properties of the complexes were recorded. Both complexes have strong absorption peaks at around 375 nm and display lipoxygenase activity.