A Novel Method for Indomethacin Determination Based on Graphene Loaded Nickel Oxides Nanoparticles Film

A novel method was described for sensitive voltammetric determination of indomethacin based on a graphene loaded nickel oxides nanoparticles (Gr-NiO) film by one-step electrodeposition. The as-prepared electrode (Gr-NiO/GCE) was characterized by electrochemical methods and scanning electron microscopy. The electrocatalytic properties of Gr-NiO/GCE toward the oxidation of indomethacin were analyzed via cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The results indicate that the one-step prepared Gr-NiO/GCE can remarkably enhance electrocatalytic activity towards the oxidation of indomethacin. Under optimized conditions, voltammetric response of Gr-NiO/GCE was linear to indomethacin within the concentration range of 2.0×10 -7 -7.0×10 -5 mol L -1 , with the detection limit of 5.4×10 −8 mol L −1 (S/N=3). And, the method was also applied to detect indomethacin in pharmaceutical dosage forms with wonderful satisfactory.