Lanthanum doped zirconium oxide-nanocomposite as sensitive electrochemical platforms for Tenofovir detection

Tenofovir (TFV) is an antiviral drug base for the treatment of diseases caused by retroviruses. Quantitative detection is the key to the effective application of TFV. In this work, a composite modified electrode (La 2 O 3 -ZrO 2 -MWCNTs/GCE) was prepared and used for the electrochemical detection of TFV. The materials were characterized by XRD, SEM, EDS. The performance of the sensor was investigated by cyclicvoltammetry, electrochemical impedance specttoscopy and differential pulse voltammetry. La 2 O 3 -ZrO 2 -MWCNTs/GCE greatly improved the electrochemical response of TFV. Under optimal conditions, the proposed electrochemical method, ranging from 0.7−100.0 μM had a good linear range with a detection limit of 0.219 μM. The sensitivity, reproducibility and selectivity of the sensor achieved satisfactory results, and has been applied to the determination of TFV in biological samples, with satisfactory results.