Physicochemical and Anti-bacterial Properties of Novel Osthole-Menthol Eutectic System

Deep eutectic solvents (DES), as a new type of green solvent, show great advantages of easy preparation and no need of purification after synthesis and great potential applications in various fields. Osthole has shown wide variety of pharmacological functions like antimicrobial, anti-inflammatory, antioxidant, or anti-cancerous. To explore the efficient delivery of osthole, we have designed a new DES based on osthole and DL-menthol with molar ratio of 1:15. The interaction between osthole and DL-menthol was checked and verified by 1 HNMR and FT-IR spectra. The physicochemical properties and anti-bacterial activity of the DES were investigated. Low viscosity and higher anti-bacterial activity against S. aureus make the DES suitable for the dermal or transdermal delivery of osthole. Therefore, the results presented herein indicated that DES may serve as a new strategy for the application of active pharmaceutical ingredients.