Fabricating PDA-NOate@CuS coated NIR-activable titanium implant to realize simultaneous antiinfection and osseointegration

Titanium has been widely used as a bone implant material due to its high mechanical strength and good biocompatibility. However, implant-related infections and insufficient osteogenic activity can lead to implant failure or delay patient recovery. With that in mind, we fabricated one multifunctional implant coating material, PDA-NOate@CuS. In the as developed material, CuS, deposited in the outermost layer, not only significantly improved the photothermal properties of polydopamine (PDA), but also released Cu ion to effectively prevent bacterial adhesion. The NO-donor (NOate) with near-infrared irradiation, generated NO which strenthened antibacterial effect of materials. The in vitro antibacterial experiments proved that PDA-NOate@CuS displayed excellent S.aureus and E. coli inhibitory effect. MC3T3-E1 cells experiments results showed that PDA-NOate@CuS promoted cell adhesion, growth and mineralization. Moreover, in vivo study demonstrated that titanium implant coated with Ti@PDA-NOate/CuS markedly enhanced osseointegration, inhibited infection, with good biocompatibility. Present study paves ways for developing novel materials for implant modification, which would benefit the treatment of orthopedic disease.