Adsorption behavior of a metal organic framework of University in Oslo 67 and its application to the extraction of sulfonamides in meat samples

In this work, a dispersive solid phase extraction (d-SPE) method for sulfonamides (SAs) has been developed using a stable and mesoporous metal organic framework (University in Oslo 67, UiO-67) as adsorbent, which was synthesized by coordination of Zr 4+ ions with 4, 4-biphenyl-dicarboxylicacid (H 2 BPDC) through a facile one-pot method. Owing to the synergistic effects of π-π interaction, hydrogen bonding , hydrophobic interaction and size match between SAs and the adsorbent, the extraction performance of UiO-67 for SAs was obviously improved. The adsorption behavior , evaluated by the kinetic models , showed that the intraparticle diffusion was involved during the adsorption process. The proper match between the pore size of UiO-67 (3.49 nm) and the molecular sizes of SAs (1.1 nm × 0.65 nm) not only allowed SAs to diffuse intraparticle but also permitted them to adjust their configurations to form hydrogen bonding with the UiO-67. By combination with HPLC analysis, a simple, sensitive, accurate and precise method for detection of SAs has been established. The method proposed in this work showed good performances, including wide linearity (14.6–250 ng/g) with high correlation coefficients ( R  ≥ 0.9991), low limits of detection (LODs, 0.7–6.5 ng/g for all SAs), satisfactory precision (Intra-day RSDs ≤ 3.4%, inter-day RSDs ≤ 4.7%), and high accuracy (recovery: 83.4–103.8%). Furthermore, benefiting from the mesoporous structure and the Zr cluster center as well as the stability, UiO-67 shows great potential to be an excellent adsorbent of SPE for extraction of SAs from other complex matrices.