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Electrosynthesis of Quinazolines and Quinazolinones via an Anodic Direct Oxidation C(sp3)-H Amination/C-N Cleavage of Tertiary Amine in Aqueous Medium

Journal 2020 · IF 2.87 · 发表于 2020 年 12 月 1 日
作者: Zhenghong Zhou,Kangfei Hu,Jiawei Wang,Zhibin Li,Yan Zhang,Zhenggen Zha,Zhiyong Wang
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摘要

An electrochemical synthesis for quinazolines and quinazolinones was developed via a C(sp3)-H amination/C-N cleavage by virtue of the anodic oxidation. The reaction can be carried out in aqueous media under mild conditions to afford the desired products with high yields. The reaction mechanism was proposed after detailed investigation.