Highly sensitive electrochemical detection of paracetamol based on MnO2/MWCNTs-NH2 composite

Herein, MnO 2 nanosheets with good catalytic performance and MWCNTs-NH 2 with good conductivity were combined to form MnO 2 /MWCNTs-NH 2 composite with synergistic conductivity and catalytic performance. Subsequently, a novel PAR electrochemical sensor was constructed based on MnO 2 /MWCNTs-NH 2 composite. Some important conditions such as enrichment time, pH value of PBS and modification volume of MnO 2 /MWCNTs-NH 2 were optimized to obtain the best detection performance for PAR. The synergistic catalytic effect of MWCNTs-NH 2 and MnO 2 endowed the composite with good catalytic performance toward the oxidation of PAR. The sensor presented a wide linear range from 0.001 to 20 μM and a low detection limit of 1 nM. Additionally, the sensor exhibited satisfactory reproducibility, repeatability, stability, selectivity, and was successfully applied for the detection of PAR in urine samples.