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Ruthenium-Catalyzed Meta-Selective Trifluoroisopropylation of Arenes

Journal 2024 · IF 3.3 · 发表于 2024 年 6 月 5 日
作者: Shuxiong Han,Min Liang,Wenjie Ju,Junrui Wang,Xu Xu,Zhibin Huang,Yingsheng Zhao
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摘要

This work reports the mild and efficient Ru-catalyzed trifluoroisopropylation of arenes using 2-bromo-1,1,1-trifluoropropane. Various bioactive molecules, such as purine and nucleoside derivatives, were well-suited for this transformation, affording the corresponding products in moderate-to-good yields. This method provides an efficient strategy for synthesizing trifluoroisopropyl molecules for drug discovery.