Layer-by-layer Assembled Multilayers of Graphene/Mono-(6-amino-6-deoxy)-β-cyclodextrin for Detection of Dopamine

Graphene/mono-(6-amino-6-deoxy)- β -cyclodextrin multilayer films composed of graphene sheet (GS) and mono-(6-amino-6-deoxy)- β -cyclodextrin (NH 2 - β -CD) were fabricated easily by two steps. First, negatively charged graphene oxide (GO) and positively charged mono-(6-amino-6-deoxy)- β -cyclodextrin (NH 2 - β -CD) were layer-by-layer (LBL) self-assembled on glassy carbon electrode (GCE) modified with a layer of poly(diallyldimethylammonium chloride) (PDDA). Then graphene/mono-(6-amino-6-deoxy)- β -cyclodextrin (GS/NH 2 - β -CD) multilayer films were built up by electrochemical reduction of graphene oxide/mono-(6-amino-6-deoxy)- β -cyclodextrin (GO/NH 2 - β -CD). Combining the high surface area of GS and the active recognition sites on β -cyclodextrin ( β -CD), the GS/NH 2 - β -CD multilayer films show excellent electrochemical sensing performance for the detection of DA with an extraordinary broad linear range from 2.53 to 980.05 µmol·L −1 . This study offers a simple route to the controllable formation of graphene-based electrochemical sensor for the detection of DA.